Convergence of Fcg Receptor IIA and Fcg Receptor IIIB Signaling Pathways in Human Neutrophils

The Use of Allele-Specific Recombinant Fcg Receptor IIIb Antigens for the Detection of Granulocyte Antibodies

The Fcg receptor IIIb (FcgRIIIb) for the Fc domain of IgG is expressed exclusively on neutrophils. The FcgRIIIb bears allotypic polymorphisms referred to as NA1, NA2, and SH, which are known for their frequent involvement in alloimmune and autoimmune neutropenias as well as in transfusion reactions. The bactericidal capacity of isolated neutrophils is easily activatable, and activation results ...

Fcg Receptor IIb Strongly Regulates Fcg Receptor- Facilitated T Cell Activation by Dendritic Cells

Inhibition of Fc g Receptor - Mediated Phagocytosis by a Nonphagocytic Fc g Receptor

There are three major classes of human Fcg receptors (FcgRI, FcgRII, and FcgRIII) and various isoforms of each class are capable of mediating phagocytosis. FcgRIIA is an unusual Fcg receptor in that it transmits a phagocytic signal in the absence of an additional receptor subunit. The cytoplasmic domain of FcgRIIA contains a conserved motif containing two copies of the sequence YXXL. The tyrosi...

C-Reactive Protein Causes Insulin Resistance in Mice Through Fcg Receptor IIB–Mediated Inhibition of Skeletal Muscle Glucose Delivery

Elevations in C-reactive protein (CRP) are associated with an increased risk of insulin resistance. Whether CRP plays a causal role is unknown. Here we show that CRP transgenic mice and wild-type mice administered recombinant CRP are insulin resistant. Mice lacking the inhibitory Fcg receptor IIB (FcgRIIB) are protected from CRP-induced insulin resistance, and immunohistochemistry reveals that ...

Fcg Receptors Inhibit Mouse and Human Basophil Activation